2024, a Journey with Purpose 

Ser Casasandra, more than a boutique hotel is a holistic home on Holbox Island, nestled in the Mexican Caribbean. Here, you can rest in your own way or in the way we propose. For over 20 years, we have blended the practice of knowledge, art, therapy, spirituality, integration with nature, and the surrounding community into a journey designed to traverse the four seasons of the soul, bringing you closer to the light beings we are.

Perhaps embarking on a purposeful journey intrigues you. 

Lounge at Ser Casasandra full of art pieces, Mexico


Art is one of the pillars of this house and in every space it is present as a way of life. Ser Casasandra is full of art pieces that are meant to make you feel in a gallery with the best ocean view. The hotel is fortunate that several artists have shared their works and these merge with the architecture, design and nature as a whole.

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Spiritual woman from Holistic Center in Holbox

AHAL Holistic Center

Ser Casasandra is a refuge for those seeking spiritual restoration. Here lies Ahal, the first Holistic Center in Holbox. With renowned therapists, wellness programs, therapies, yoga,  and spiritual retreats, you can reconnect with your body, soul and the present moment. This place is a safe refuge to delve into your mind.

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Ser Casasandra's mission is to guide the experience of its guests from a more conscious relationship of enjoyment and respect for nature and culture in Holbox. In the community we remember that we are ONE. Through empathy we connect with a greater purpose, that of collaborating for collective evolution.

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Woman walking on the beach of Holbox Island


Home to local fishermen and adventure-seekers, Holbox is an oasis of vibrant culture where Mayan traditions weave into every-day customs. The island forbids cars, high-rises and formality. Sandy roads lead the way to a sundrenched beach that seamlessly blends into an endless horizon. From your arrival, the island will invite you to relieve your everyday stress.

The shadow of a palm tree on the sand of Holbox Island


Learn why Holbox is one of Mexico's best kept secrets, an oasis of true unspoiled nature.

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Woman playing with her pet in the beach


Enhance your stay with attractions and activities that will make memories last a lifetime.

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With designer furnishings and striking decor, we invite you to luxuriate in Ser Casasandra's lavish boho-chic accommodations. Our accommodations purposely exclude televisions, telephones, alarm-clocks and radios so you can enjoy soothing quietude. Our property is elegantly decorated with original works of art by Sandra Perez, and other renowned artists from the Arsenal Habana Gallery and Isla Residencia.


Newest rooms in the house. It is located on the top floor of the main building, overlooking the sea. These rooms offer the perfect setting for couples, or for those looking to relax and disconnect. Enjoy ocean views from a private balcony with handmade hammock.


Each of our master suites are designed for relaxation and comfort. Your place to leave the world behind, a space that seeks to inspire.


With partial views of pool, gardens and ocean, Miracle suite is located in the upper floor of the main building. Originally a family room, the space designed by the owner. Sensibility and Light suites are located in a beautiful independent little casita; they offer a living room, dining room, private balcony with a hanging artisanal hammock, independent dressing room and spacious bathroom and shower.


With rustic, yet elegant décor, Inspiration suite overlooks lush tropical gardens.

Luxury residence: The ORigin

Origin is a luxurious apartment that is located in the main building, with a private entrance. It has a master bedroom with a king size bed and private bathroom and a second small guest bedroom with a single bed. It has a fully equipped kitchen area, a dining room for 8 guests, a spacious living room and a private balcony with ocean view, as well as a guest bathroom. Maximum capacity of 3 people.

Chef at Ser Casasandra
Gourmet At Ser Casasandra, Mexico
Gourmet At Ser Casasandra, Mexico


Diverse and original dining experiences are all yours to enjoy at Ser Casasandra. Every meal is a culinary expression of the local land and culture. Relish in our delectable dining venues, and experience vibrant flavors and award winning recipes, bursting with unique style and personality.

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Tables at Mojitos Beach Club


Shed your old-world view and adopt a new one as you soak-up breathtaking ocean views at Mojito's. You will enjoy authentic Cuban cuisine and the best mojitos in town.

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Maiz Pool Bar


Enjoy exquisite cuisine while working from your laptop or simply relaxing with your favorite cocktail or a healthy smoothie in hand next to the pool.

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Ser Esencia Restaurant


Offering distinguished cuisine since 2004, Ser Esencia has been recommended by The New York Times as one of the hottest eateries in the whole of Holbox.

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Terrace at the boutique-hotel Ser Casasandra in Holbox Island, Mexico


Holbox provides the ideal setting to do it all. Steeped in the island's "be yourself" philosophy, this enticing caribbean spot features a full host of experiences and activities. Treat yourself to a deep-tissue massage at our holistic center. Join us for a yoga retreat. Take a tour and explore unspoiled nature. Or simply choose to relax and enjoy island life at its best.

Fish in the water


Our custom packages will ignite your senses, book direct and enjoy benefits.

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Person walking in the sea


Learn more about our special offers and begin a picture-perfect journey.

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Choose to love and celebrate a wedding that honors an everlasting connection to your partner and to the universe that binds us. At Ser Casasandra, we are here to help you design a carefree beach wedding.

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Porter Logo

"If your idea of romantic relaxation is to kick off your shoes and pad around in a sarong all day, then Ser CasaSandra is your boho beach paradise:"

Forbes Logo

"My clients stayed at CasaSandra, a boutique hotel without televisions, went bird-watching, fishing, swimming with whale sharks, ate great seafood and came back rejuvenated."

Conde Nast Traveller Logo

"Ultra-personalised service from artist-owner Sandra Pérez Lozano and front-of-house Antonio Llinas makes a stay here rather special. There's a brilliantly positioned beach bar, top-notch food (yucca salad with lobster) and morning yoga."

The New York Times logo

"By general consensus, the best restaurant on the island is at Casa Sandra hotel, where diners sip mojitos by candlelight and the Cuban chef visits each table to describe the specials."

Citizen Femme logo

"It wasn't too long before she opened up CasaSandra to paying guests. With 18 rooms only, Sandra created a place you may never want to leave."

Lampoon logo

At Artist Sandra Pérez Lozano's house, guests live in harmony with the natural world, promoting consciousness and respect towards the environment - the inhabitants and the culture of Holbox island.

Natural style logo

Once settled in the comfortable Ser Casasandra, you understand all the beauty of this place on the Caribbean Sea, still far from the travel circuits.

Boston magazine logo

Ser Casasandra is an art hotel that boasts two of the island's finest restaurants: Ser Esencia, which was lauded by the New York Times, and the toes-in-the-sand Mojito's Beach Club, serving local and Cuban cuisine.